The study was conducted to evaluate
and analyze the ocular side effects of antihypertensive drugs in the patients
and to determine the effects of antihypertensive drugs in causing dry eye
disease and intra ocular pressure changes. This was a case-control,
non-interventional study of 140 patients (70 cases and 70 controls) conducted
from June 2014 to May 2015 in Dr. Rajendra Prasad Government Medical College,
Kangra at Tanda, Himachal Pradesh (India).
Patients were subjected to detailed
history and examination using standardized protocol and Performa. The
prevalence of dry eye in this study was 44.3% in cases and 7.1% in controls, with
p value of 0.0001 (<0.05), which is significant. Dry eye was present in allthe patients on beta blockers and thiazide diuretics (alone or withcombination). Dry eye disease was significantly associated with increasing age
and longer duration of antihypertensive treatment. It was observed that average
IOP was lower in patients on antihypertensive treatment as compared to normal
subjects.
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