Vogt-Koyanagi-Harada
(VKH) syndrome is a bilateral granulomatous uveitis that typically presents
with distinct clinical features based on the duration and stage of the disease.
The acute stage of VKH is characterized by diffuse choroiditis, multifocal
areas of subretinal fluid and/or bullous serous retinal detachments, with or
without neurologic (headaches, meningismus) or auditory (tinnitus, hypoacusia)
symptoms.
The convalescent stage of the disease develops 12 weeks after onset
and is characterized by resolution of retinal detachments with disappearance of
cells from the anterior chamber and the vitreous, with characteristic
pigmentary changes in the macula and sunset glow fundus. The chronic/recurrent
phase is characterized by clinical signs of disease activity in the anterior
segment of the eye with anterior granulomatous uveitis and dermatologic signs
(vitiligo, alopecia, poliosis).
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