To report long-term results in a
case series of patients treated with systemic immune suppression for prevention
of penetrating keratoplasty (PKP) graft rejection. Retrospective non comparative
chart review. Three patients presented with PKP graft failure.
Patients received oral prednisone, azathioprine and cyclosporine to
prevent rejection of repeat corneal transplant. Patients received repeat PKPand graft outcome was reported. Main outcome measures: Visual acuity and graft
survival were recorded. Mean age was 55 years, two male and one
female. Mean follow-up period was 37 months (range 24- 46). All three patients
completed the treatment protocol with minimal adverse effects. All grafts
remained clear over observational period. Conclusion: Our study suggests that
systemic immune suppression with 2 or more agents may be helpful to prevent
corneal graft rejection in high-risk patients.
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