These are the proteins in humans that are associated with Cross-Linked Actin Networks in Trabecular Meshwork Cells

The majority of the aqueous humor, which is produced by the ciliary body, is drained through the conventional outflow pathway. In this pathway, the aqueous humor flows from the posterior chamber to anterior chamber and exits the eye through the trabecular mesh work(TM), a multilayered tissue in the iridocorneal angle of the eye.

In primary open angle glaucoma (POAG), glucocorticoid-induced ocular hypertension (GC-OHT), and glucocorticoid induced glaucoma (GIG), the outflow resistance at the TM is increased, which causes intraocular pressure (IOP) elevation. Elevated IOP is the major risk factor for the development and progression of glaucoma that leads to irreversible visual loss that can cause blindness.